凯发

Graphene’s unique structural elements, including being a single-atom thick, two-dimensional and extensively conjugated, endow graphene with advantageous biocompatibility and thermal, electric and mechanical properties, which enhance its potential for application in drug delivery[1,2] and the preparation of ultrasensitive sensors. [3-5] In this presentation, we report the preparation of a pH-sensitive graphene/poly (acrylic acid) hydrogel in situ RAFT polymerization for controlled drug release (Fig.1).[1] The preparation of biodegradable and positively charged graphene/poly(2-(dimethylamino) ethylacrylate) nanocomposite for DNA uptake and release is also presented.[2] Gold electrode can also be modifided with graphene via non-covalent interaction for the analysis of heavy metals.[3] The as-prepared electrodes exhibited high detection sensitivity with the lowest detection limit of 1.5 nM for Cu2+ and 0.4 nM for Pb2+ solutions, respectively. Furthermore, when glucose oxidase (GOx) was modified with surface-bound pyrene functionalities it can be self-assembled onto graphene nanosheets via non–covalent π–π stacking interaction to afford multi-layered enzyme electrode with a broad lineardetection limit of 0.2 to 40 mM and sensitivity.[4] In addition, highly oriented pyrolytic graphite (HOPG) electrodes modified with pyrene functionalised biotin (PFB) via π−π stacking and ethylene glycol anti−fouling molecules via covalent bonding for streptavidin analysis is also presented. The as−prepared biotinylated electrode was used as the sensing probe to analyze the concentration of streptavidin via the electrochemistry diminution resulted from the desorption rate of pyrene modified biotin mediated by biotin−streptavidin recognition (Fig.2).[5]

References:

[1] J. Liu*, L. Cui, N. Kong, C. Barrow, W. Yang, European Polymer Journal, 50 (2014) 9-17 

[2] J. Liu, Z. Liu, X. Luo, X. Zong, J. Liu*, Macromolecular Chemistry and Physics, 214 (2013) 2266−2275 

[3] N. Kong, J. Liu*, Q. Kong, R. Wang, C. Barrow, W. Yang, Sensor Actuat B-Chem, 178 (2013) 426-433

[4] J. Liu*, N. Kong, A. Li, X. Luo, L. Cui, R. Wang and S. Feng, Analyst, 138 (2013) 2567-2575

[5] N. Kong, J. J. Gooding, J. Liu*, Journal of Solid State Electrochemistry, Accepted